Here is a before picture of my lovely office. How embarrassing! It didn't get this way overnight, but it is in sad shape.
I started with the desktop and a laundry basket. Took everything off, wiped it all down and put it back. My office area is more of a storage area for my painting, scrapbooking and craft supplies. You can still see the mess under the desk, but I'm getting there. I have a large bag of trash and a box of sell/donate.
Here is the desk top all cleaned up. A few of the items will go up on the first shelf when it's ready. So it's not quite cleared off yet.